Loading...
Search for:
thiopyran
0.009 seconds
Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions
, Article Heliyon ; Volume 8, Issue 9 , Volume 8, Issue 9 , 2022 ; 24058440 (ISSN) ; Aghamiri, B ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
An efficient and facile one-pot, five-component reaction for the synthesis of 2,6-diamino-1-alkyl-2-oxospiro[indoline-3,4′-thiopyran]-3,5-dicarbonitrile derivatives has been reported by a reaction between primary amines, carbon disulfide, malononitrile, and isatin derivatives. The major advantages of this procedure are high yields of products in relatively short reaction time, scalability, mild conditions, multi-component synthetic procedure, low catalyst loading, no column separation and simple reaction work-up. As a consequence, this synthetic procedure provided an efficient access to spirooxindole-annulated thiopyran derivatives. © 2022
A new domino Knoevenagel-hetero-Diels-Alder reaction: An efficient catalyst-free synthesis of novel thiochromone-annulated thiopyranocoumarin derivatives in aqueous medium
, Article Tetrahedron ; Volume 66, Issue 45 , November , 2010 , Pages 8615-8622 ; 00404020 (ISSN) ; Kiamehr, M ; Khodabakhshi, M. R ; Mirjafary, Z ; Fathi, S ; Saeidian, H ; Sharif University of Technology
2010
Abstract
An efficient catalyst-free synthesis of novel pentacyclic thiochromone-annulated thiopyranocoumarin derivatives is achieved via domino Knoevenagel-hetero-Diels-Alder reaction of 4-hydroxy dithiocoumarin and O-acrylated salicylaldehyde derivatives in H2O as solvent. The products are formed in good yields with high regio- and stereo-selectivity