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thiopyrano-indole
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Synthesis of novel pentacyclic thiopyrano indole-annulated benzo-δ-sultone derivatives via a domino Knoevenagel-hetero-Diels-Alder reaction in water
, Article Tetrahedron Letters ; Volume 54, Issue 21 , 2013 , Pages 2685-2689 ; 00404039 (ISSN) ; Khodabakhshi, M. R ; Kiamehr, M ; Ghahremannejad, Z ; Sharif University of Technology
2013
Abstract
An efficient synthesis of novel pentacyclic thiopyrano indole-annulated benzo-δ-sultone derivatives is achieved via intramolecular domino Knoevenagel-hetero-Diels-Alder reaction of 2-formylphenyl (E)-2-phenylethenyl sulfonates and indoline-2-thiones in aqueous medium. The products are formed in good yields with high regio- and stereoselectivity