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    Fabrication of a highly ordered hierarchically designed porous nanocomposite via indirect 3D printing: Mechanical properties and in vitro cell responses

    , Article Materials and Design ; Volume 88 , 2015 , Pages 924-931 ; 02641275 (ISSN) Tamjid, E ; Simchi, A ; Sharif University of Technology
    Elsevier Ltd  2015
    Design and development of biodegradable scaffolds with highly uniform and controlled internal structure that stimulate tissue regeneration are the focus of many studies. The aim of this work is to apply a modified three-dimensional (3D) printing process to fabricate polymer-matrix composites with controlled internal architecture. Computationally-designed plaster molds with various pore sizes in the range of 300-800. μm were prepared by employing 3D printing of a water-based binder. The molds were converted to ε-polycaprolactone (PCL) and PCL/bioactive glass (BG) composite scaffolds by solvent casting and freeze drying methods. Optical and electron microscopy studies revealed that the pore...