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    Numerical Modeling of Blood Coagulation in Stenosis

    , M.Sc. Thesis Sharif University of Technology Kord, Ali (Author) ; Taghizadeh Manzari, Mehrdad (Supervisor) ; Shamloo, Amir (Co-Advisor)
    Trombosis formation in blood flow is a complex biochemical and very important process for body health which impedes blood loss by creating obstacles in the path of injured wall vessels. Although this phenomenon plays a very significant role in healthy body function, unfortunately it has been observed that it could cause diseases or even stroke. The reason is that thrombosis formation in blood and its detachment from the vessel wall can result in block body capillaries and lead a catastrophic event for the body. One of the factors which motivates blood for forming unnatural thrombosis is the vessel stenosis. It would ange in normal blood flow path and cause thrombosis formation as time is... 

    Computational Study on the Evaluation of Antihemophilic Factors Effect on Clot Formation

    , M.Sc. Thesis Sharif University of Technology Barzegar, Saeed (Author) ; Assempour, Ahmad (Supervisor) ; Ahmadian, Mohammad Taghi (Supervisor)
    Many heart attacks and strokes are caused by improper clot formation in the vascular system. Mathematical understanding of the clot formation process and the influence of various factors in the clot formation process is very important. In this study, the aim is to simulate and understand the clotting process mathematically by considering natural, external and general mechanisms in the clotting process. In this process, when damage occurs in the endothelial region of the vessel, tissue factor is released and 38 different substances react with each other inside the plasma, eventually forming fibrin. To simulate the movement of different chemical components and proteins in plasma, the... 

    Numerical Study of Margination and Adhesion of Micro- and Nano-particles in Coronary Circulation

    , M.Sc. Thesis Sharif University of Technology Forouzandehmehr, Mohammad Amin (Author) ; Shamloo, Amir (Supervisor)
    Obstruction of Left Anterior Descending artery (LAD) due to thrombosis or atherosclerotic plaques is the leading cause of death world–wide. Targeted delivery of drugs through micro- Nano-particles holds noteworthy promise which can make clot busting or the restenosis treatment with minimal toxicity possible. In this work, Fluid-Structure Interaction (FSI) simulations of blood flow through a patient-specific reconstructed geometry of LAD artery have been conducted using a non-Newtonian hematocrit (HCT) dependent model for blood. Based on physiological facts, 25, 45 and 65 percentages of HCT were assumed as acceptable representations of anemic, healthy and diabetic blood conditions,... 

    Margination and adhesion of micro- and nanoparticles in the coronary circulation: A step towards optimised drug carrier design

    , Article Biomechanics and Modeling in Mechanobiology ; Volume 17, Issue 1 , 2018 , Pages 205-221 ; 16177959 (ISSN) Forouzandehmehr, M ; Shamloo, A ; Sharif University of Technology
    Springer Verlag  2018
    Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid–solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle–particle interactions. Our results state that the number of... 

    Healthy and diseasedin vitromodels of vascular systems

    , Article Lab on a Chip ; Volume 21, Issue 4 , 2021 , Pages 641-659 ; 14730197 (ISSN) Hosseini, V ; Mallone, A ; Nasrollahi, F ; Ostrovidov, S ; Nasiri, R ; Mahmoodi, M ; Haghniaz, R ; Baidya, A ; Salek, M. M ; Darabi, M. A ; Orive, G ; Shamloo, A ; Dokmeci, M. R ; Ahadian, S ; Khademhosseini, A ; Sharif University of Technology
    Royal Society of Chemistry  2021
    Irregular hemodynamics affects the progression of various vascular diseases, such atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal models, the inter-species differences between humans and animals hamper the translation of such findings. Recent advances in vascular tissue engineering and the suitability ofin vitromodels for interim analysis have increased the use ofin vitrohuman vascular tissue models. Although the effect of flow on endothelial cell (EC) pathophysiology and EC-flow interactions have been vastly studied in two-dimensional systems, they cannot be used to understand the effect of other micro- and macro-environmental parameters associated with...