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    The impact of including tRNA content on the optimality of the genetic code

    , Article Bulletin of Mathematical Biology ; Volume 67, Issue 6 , 2005 , Pages 1355-1368 ; 00928240 (ISSN) Goodarzi, H ; Shateri Najafabadi, H ; Ahmadi Nejad, H ; Torabi, N ; Sharif University of Technology
    Statistical and biochemical studies have revealed nonrandom patterns in codon assignments. The canonical genetic code is known to be highly efficient in minimizing the effects of mistranslational errors and point mutations, since it is known that, when an amino acid is converted to another due to error, the biochemical properties of the resulted amino acid are usually very similar to those of the original one. In this study, we have taken into consideration both relative frequencies of amino acids and relative gene copy frequencies of tRNAs in genomic sequences in order to introduce a fitness function which models the mistranslational probabilities more accurately in modern organisms. The...