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traumatic-brain-injury--tbi
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Effect of Linear and Rotational Acceleration on Human Brain
, M.Sc. Thesis Sharif University of Technology ; Ahmadiyan, Mohammad Taghi (Supervisor) ; Hoviattalab, Maryam (Co-Advisor)
Abstract
Traumatic brain injury (TBI) has long been known as one of the most anonymous reasons for death around the world. This phenomenon has been under study for many years and yet it remains a question due to physiological, geometrical and computational complexity. Due to limitation in experimental study on human head, the finite element human head model with precise geometric characteristics and mechanical properties is essential. In this study, the visco-hyperelastic parameters of bovine brain extracted from experimental data and finite element simulations which validated by experimental results. Then a 3D human head including brain, skull, and the meninges is modeled using CT-scan and MRI data...
Traumatic Brain Injury at Cellular Level by Using Multi-scale Modelling in Comparison with Clinical Data
, M.Sc. Thesis Sharif University of Technology ; Farahmand, Farzam (Supervisor) ; Ahmadian, Mohammad Taghi (Supervisor)
Abstract
This study aims to provide a multiscale model of traumatic brain injury including the three levels of macro, meso, and microscale information. In order to do this, a macroscale voxel-baed model of human head was constructed. The model was designed and generated to include mesoscale tissue information as well as a voxel-based approach to include voxel-based microscale data and to be coupled in a multiscale framework. Next, three different microscale models were constructed. The variations of fractional anisotropy within one standard deviation in the regions (including 60% to 70% of voxels) can change the stiffness of the tissue by up to the considerable amount of 40%. The microscale models...
Modelling and Analysis of the Effect of Angular Velocity and Acceleration on Brain Strain Field in Traumatic Brain Injury
, M.Sc. Thesis Sharif University of Technology ; Ahmadiyan, Mohammad Tagh (Supervisor) ; Zohoor, Hassan (Supervisor)
Abstract
Traumatic brain injury (TBI) has long been known as one of the most anonymous reasons for death around the world. A presentation of a model of what happens in the process has been under study for many years; and yet it remains a question due to physiological, geometrical and computational complications. Although the modeling facilities for soft tissue modeling have improved, the precise CT-imaging of human head has revealed novel details of brain, skull and the interface (the meninges), a comprehensive FEM model of which is still being studied. This study aims to present an optimized model of human head after a comprehensive study of the previous models; which includes the brain, skull, and...
Modelling and analysis of the effect of angular velocity and acceleration on brain strain field in traumatic brain injury
, Article ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) ; Volume 3 A , 2013 ; 9780791856215 (ISBN) ; Ahmadian, M. T ; Barari, A ; Beidokhti, H. N ; Sharif University of Technology
Abstract
Traumatic brain injury (TBI) has long been known as one of the most anonymous reasons for death around the world. A presentation of a model of what happens in the process has been under study for many years; and yet it remains a question due to physiological, geometrical and computational complications. Although the facilities for soft tissue modeling have improved and the precise CT-imaging of human head has revealed novel details of brain, skull and the interface (the meninges), a comprehensive FEM model of TBI is still being studied. This study aims to present an optimized model of human head including the brain, skull, and the meninges after a comprehensive study of the previous models....
3D Finite Element Modeling of Head for Studying Subdural Hemorrhage Induced by Impact
, M.Sc. Thesis Sharif University of Technology ; Naghdabadi, Reza (Supervisor) ; Sohrabpour, Saeed (Supervisor)
Abstract
Subdural hemorrhage (SDH) is one of the most common traumatic brain injuries. The mortality rate of SDH is over 30 percent. In addition, patients require to visit hospital for treatment and further healthcare. According to the costs of treatment and frequency of injuries, prevention of SDH is essential. 3D-Finite element modeling of human head is an appropriate tool for evaluation of injury risk and setting up a prevention tolerance criteria. The aim of this study is to create a 3D finite element model of human head with special consideration of vessels. Vessels are modeled by truss elements at current finite element models of human head; however, geometry of vessels is regarded as simple...
Comparison of transplantation of bone marrow stromal cells (BMSC) and stem cell mobilization by granulocyte colony stimulating factor after traumatic brain injury in rat
, Article Iranian Biomedical Journal ; Volume 14, Issue 4 , Oct , 2010 , Pages 142-149 ; 1028852X (ISSN) ; Marzban, M ; Mehdizadeh, M ; Joghataei, M. T ; Khoei, S ; Pirhajati Mahabadi, V ; Laribi, B ; Tondar, M ; Moshkforoush, A ; Sharif University of Technology
2010
Abstract
Background: Recent clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to compare effect of intravenous injection of bone marrow mesenchymal stem cells (BMSC) and bone marrow hematopoietic stem cell mobilization, induced by granulocyte colony stimulating factor (G-CSF), in rats with a cortical compact device. Methods: Forty adult male Wistar rats were injured with controlled cortical impact device and divided randomly into four groups. The treatment groups were injected with 2 × 106 intravenous bone marrow stromal stem cell (n = 10) and also with subcutaneous G-CSF (n = 10) and sham-operation group (n = 10) received PBS and "bromodeoxyuridine...