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tree-like-concentration-gradient-generator
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Design and Fabrication of a Microfluidic System for Simultaneous Delivery of Two Reagents on a Millimeter-Sized Tissue
, Ph.D. Dissertation Sharif University of Technology ; Saeedi, Mohamad Saeed (Supervisor) ; Kashaninejad, Navid (Co-Supervisor)
Abstract
It is of great interest to investigate the effects of different concentrations of chemical species on the behavior of test samples. For example, while developing a new drug, pharmacologists are concerned with the behavior of the live sample against different drug concentrations. Microfluidic systems are the new engineering platforms developed for simplifying these experiments. The main goal of the current study is the design and fabrication of a microfluidic system with the capability of generating a continuous concentration gradient from two species simultaneously on a millimeter-sized test sample. Such a system creates many benefits for researchers using microfluidics technology. Our...
A tool for designing tree-like concentration gradient generators for lab-on-a-chip applications
, Article Chemical Engineering Science ; Volume 212 , 2020 ; Moshksayan, K ; Kashaninejad, N ; Saidi, M. S ; Nguyen, N. T ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Concentration gradient generators (CGGs) help biologists to perform large scale, fast and high-throughput experiments. This paper introduces a design tool called Tree-like Concentration gradient generator Design Tool (TCDT). The performance of this tool is validated both numerically and experimentally. Three CGGs were fabricated using three different fabrication methods and design parameters. The performance of these devices was examined using the measurement of fluorescent and dye intensity. The performance of the design tool for non-linear and multi-drug concentration gradient generations was investigated as well. In addition, a method was developed to investigate the multi-drug...