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tumor-growth
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Existence and Uniqueness of Solution for Two Free Boundary Problems Modelling Tumor Growth
,
M.Sc. Thesis
Sharif University of Technology
;
Hesaaraki, Mahmoud
(Supervisor)
Abstract
This thesis is based on articles [18,15]. Zhao [18] has studied a free boundary problem modeling the growth of tumors with drug application. In this model live cells are two kindes: proliferative cells and quiescent cells. This model consists of two nonlinear second-order parabolic equations describing the diffusion of nutrient and drug concentration, and three nonlinear first-order hyperbolic equations describing the evolution of proliferative cells, quiescent cells and dead cells. He has proved that this free boundary problem has a unique global solution. Tao and Chen [15] have studied another free boundary problem modelling the growth of an avascular tumour with drug application. The...
Evolutionary Dynamics of Tumorigenesis: An Application of Dynamical Systems
, M.Sc. Thesis Sharif University of Technology ; Alishahi, Kasra (Supervisor) ; Razvan, Mohammad Reza (Co-Supervisor)
Abstract
Application of optimal control in cancer modeling is studied through both linear and nonlinear modeling of the dynamics in ordinary differential equations. At the outset, a fairly straight-forward analysis of a linear model in presented. Through comparably simple machinery, this seminal work published at early 2000s covers some of most important techniques previously developed. The model here is infinite- dimensional, taking different number of gene amplifications into account. Thereafter by surveying recently published papers, the literature is reviewed and different lines of progress is followed, culminating in detailed study of a specific approach which is theoretically of interest....
Mathematical Modeling and Simulation of Tumor Angiogenesis
, M.Sc. Thesis Sharif University of Technology ; Fotouhi, Morteza (Supervisor)
Abstract
A major medical revolution that is helping us overcome some of the worst diseases, including cancer, is angiogenesis, which is based on the processes our bodies use to develop blood vessels. Most human cancers have acquired six essential capabilities: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, programmed cell death escape, unlimited replication potential, persistent angiogenesis, and tissue invasion that can induce metastasis. In other words, the defense mechanism that prevents any of these acquired capabilities must be neutralized before the cells become malignant and invasive tumors. In fact, tumors in the non-vascular growth stage can only grow up to...
Three-dimensional modeling of avascular tumor growth in both static and dynamic culture platforms
, Article Micromachines ; Volume 10, Issue 9 , 2019 ; 2072666X (ISSN) ; Barisam, M ; Saidi, M. S ; Kashaninejad, N ; Nguyen, N. T ; Sharif University of Technology
MDPI AG
2019
Abstract
Microfluidic cell culture platforms are ideal candidates for modeling the native tumor microenvironment because they can precisely reconstruct in vivo cellular behavior. Moreover, mathematical modeling of tumor growth can pave the way toward description and prediction of growth pattern as well as improving cancer treatment. In this study, a modified mathematical model based on concentration distribution is applied to tumor growth in both conventional static culture and dynamic microfluidic cell culture systems. Apoptosis and necrosis mechanisms are considered as the main inhibitory factors in the model, while tumor growth rate and nutrient consumption rate are modified in both quiescent and...
Mathematical Modeling and Simulation of Hyperbaric Oxygen Therapy in Tumor Growth Process
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaei, Mohammad Jafar (Supervisor) ; Saadatmand, Maryam (Co-Supervisor)
Abstract
Today cancer is one of the leading causes of death worldwide. It is caused by some cells that they gather together in part of the body and they have an abnormal and very high proliferation rate. Investigations on tumors have shown that when tumor volume increases, oxygen concentration in some regions of tumors decreases and this hypoxic condition leads to some cancer hallmarks, e.g. angiogenesis, deregulation of apoptosis, and shift in cell energy sources. So treatment strategies that can increase tissue oxygenation are good choices for cancers. Hyperbaric oxygen therapy (HBOT) which is used to treat diabetic ulcers and carbon monoxide poisoning, have been used experimentally for cancer and...
Multi-scale Simulation of Tumor Microenvironment
, M.Sc. Thesis Sharif University of Technology ; Firoozabadi, Bahar (Supervisor) ; Mozafari, Ali Asghar (Co-Supervisor)
Abstract
Search for effective methods for treating cancer requires a deep understanding of the tumor microenvironment and its role in cancerous tumor growth and progression. Mathematical modeling methods, which have fewer limitations than experimental methods for examining the microcirculation of cancer in detail, are suggested to answer many questions about the behavior and dynamics of cancerous tumors. In the present study, a multi-scale mathematical model of the three-dimensional tumor microenvironment, including molecular, cellular, and tissue scales, is presented. In this model, important aspects of tumor microenvironmental dynamics including tumor growth, angiogenesis, cancer metabolism, and...
Constitutive Modeling of Nonlinear Tumor Growth; A Finite Element Approach
,
M.Sc. Thesis
Sharif University of Technology
;
Naghdabadi, Reza
(Supervisor)
Abstract
Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate and induces apoptosis. Additionally, compression of intratumor blood vessels has negative impacts on drug delivery system. Despite the great importance of the mechanical forces on the pathology of cancer, there are limited studies on the constitutive modeling of tumors. In this study, first, the tumor growth inside a rigid cylinder with an exponential growth function is represented, a model mimicking the growth of ductal carcinoma. Then, a mathematical model of a spherical tumor growth with a Gompertz growth function is represented. Using the notion of multiple...
Chemo-mechanistic multi-scale model of a three-dimensional tumor microenvironment to quantify the chemotherapy response of cancer
, Article Biotechnology and Bioengineering ; Volume 118, Issue 10 , 2021 , Pages 3871-3887 ; 00063592 (ISSN) ; Firoozabadi, B ; Mozafari, A ; Sharif University of Technology
John Wiley and Sons Inc
2021
Abstract
Exploring efficient chemotherapy would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. As in vivo experimental methods are unable to isolate or control individual factors of the TME, and in vitro models often cannot include all the contributing factors, some questions are best addressed with mathematical models of systems biology. In this study, we establish a multi-scale mathematical model of the TME to simulate three-dimensional tumor growth and angiogenesis and then implement the model for an array of chemotherapy approaches to elucidate the effect of TME conditions and drug scheduling on controlling tumor progression. The...
Investigation of cancer response to chemotherapy: a hybrid multi-scale mathematical and computational model of the tumor microenvironment
, Article Biomechanics and Modeling in Mechanobiology ; Volume 21, Issue 4 , 2022 , Pages 1233-1249 ; 16177959 (ISSN) ; Firoozabadi, B ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Tumor microenvironment (TME) is a multi-scale biological environment that can control tumor dynamics with many biomechanical and biochemical factors. Investigating the physiology of TME with a heterogeneous structure and abnormal functions not only can achieve a deeper understanding of tumor behavior but also can help develop more efficient anti-cancer strategies. In this work, we develop a hybrid multi-scale mathematical model of TME to simulate the progression of a three-dimensional tumor and elucidate its response to different chemotherapy approaches. The chemotherapy approaches include multiple low dose (MLD) of anti-cancer drug, maximum tolerated dose (MTD) of anti-cancer drug,...
Oncolytic newcastle disease virus delivered by mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment
, Article Virology Journal ; Volume 17, Issue 1 , 2020 ; Ebrahimzadeh, M. S ; Miri, S. M ; Dianat Moghadam, H ; Ghorbanhosseini, S. S ; Mohebbi, S. R ; Keyvani, H ; Ghaemi, A ; Sharif University of Technology
BioMed Central Ltd
2020
Abstract
Background: Human papillomavirus (HPV)-associated malignancy remain a main cause of cancer in men and women. Cancer immunotherapy has represented great potential as a new promising cancer therapeutic approach. Here, we report Mesenchymal stem cells (MSCs) as a carrier for the delivery of oncolytic Newcastle disease virus (NDV) for the treatment of HPV-associated tumor. Methods: For this purpose, MSCs obtained from the bone marrow of C57BL mice, then cultured and characterized subsequently by the flow cytometry analysis for the presence of cell surface markers. In this study, we sought out to determine the impacts of MSCs loaded with oncolytic NDV on splenic T cell and cytokine immune...
Synergy between hemagglutinin 2 (HA2) subunit of influenza fusogenic membrane glycoprotein and oncolytic Newcastle disease virus suppressed tumor growth and further enhanced by Immune checkpoint PD-1 blockade
, Article Cancer Cell International ; Volume 20, Issue 1 , August , 2020 ; Ebrahimzadeh, M. S ; Abdolalipour, E ; Yazdi, M ; Hosseini Ravandi, H ; Ghaemi, A ; Sharif University of Technology
BioMed Central Ltd
2020
Abstract
Background: Newcastle disease virus (NDV) has shown noticeable oncolytic properties, especially against cervical cancer. However, in order to improve the spread rate and oncotoxicity of the virus, employment of other therapeutic reagents would be helpful. It has been shown that some viral fusogenic membrane glycoproteins (FMGs) could facilitate viral propagation and increase the infection rate of tumor cells by oncolytic viruses. Additionally, immune checkpoint blockade has widely been investigated for its anti-tumor effects against several types of cancers. Here, we investigated for the first time whether the incorporation of influenza hemagglutinin-2 (HA2) FMG could improve the oncolytic...
Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect
, Article Cancer Nanotechnology ; Volume 12, Issue 1 , 2021 ; 18686958 (ISSN) ; Akbarzadeh, I ; Marzbankia, E ; Farid, M ; khaledi, L ; Reihani, A. H ; Javidfar, M ; Mortazavi, P ; Sharif University of Technology
BioMed Central Ltd
2021
Abstract
Background: Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 and SKBR3 breast cell lines and in vivo on BALB/C inbred mice. "Thin-layer hydration method" was used for preparing the niosomes; different niosomal formulations of melittin were prepared and characterized in terms of morphology, size, polydispersity index, encapsulation efficiency, release kinetics, and stability. A niosome was formulated and loaded with melittin as a promising drug carrier system for chemotherapy of the breast cancer cells....