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tumor-therapy
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Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol-g-polycaprolactone with pH-responsive behavior: designed for targeted and controlled doxorubicin delivery
, Article Journal of Industrial and Engineering Chemistry ; 2015 ; ISSN: 1226086X ; Tehrani, Z. M ; Jokar, S ; Sharif University of Technology
Abstract
In the present work a novel multifunctional drug nanocarrier was prepared. Polyglycerol-. g-polycaprolactone was grafted on Mesoporous silica-coated magnetic graphene oxide. Doxorubicin, as anticancer drug, was loaded on this carrier. The in vitro drug release showed the controlled pH responsive behavior. At the endosomal pH (pH 5.5) the amount of drug release enhanced. This nanocarrier would have potential application in the tumor therapy owing to its biodegradability, controlled release and pH responsive behavior
Cellular model of electroporated tissue for ultrasound RF data analysis
, Article 2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009, Beirut, 15 July 2009 through 17 July 2009 ; 2009 , Pages 652-655 ; 9781424438341 (ISBN) ; Zahedi, E ; National Instruments; MSC Software; Pro Mech ; Sharif University of Technology
2009
Abstract
Electroporation is permeabilization of the cell membrane, caused by an external electric field. Because of minimal thermal effects and minimal disturbance caused to tissue vasculature electroporation is becoming one of the methods of choice in tumor therapy. There has been no report indicating that reversible electroporation can be detected by ultrasound. In this work a cellular model for monitoring the electroporation process b; ultrasound RF signals is proposed. The density of aqueous pores with different sizes was found by applying the asymptotic model of electroporation and Smoluchowski equation. The cellular model was send to an ultrasound simulation program where pores were modeled by...