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Simulation of the Urinary Concentration Mechanism
, M.Sc. Thesis Sharif University of Technology ; Abd Khodaei, Mohammad Jafar (Supervisor) ; Farhadi, Fathollah (Supervisor)
Abstract
The kidneys serve essential regulatory roles in the body which remove excess organic molecules from the blood and the removal of waste products of metabolism. They are essential in the urinary system. Urinary concentration mechanism has long been interested for mathematicians and physiologists to elucidate the obscurities within the process. In this study, a novel three-dimensional approach is used for simulating urine concentrating mechanism in rat renal medulla. The model equations are based on three spatial dimensions mass and momentum transports. Exact 3D geometry has been designed by using COMSOL Multiphysics software and results have been compared with the latest available data. In...
Completely 3dimensional Simulation of Urine Concentrating Mechanism in Rat Outer Medulla
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firoozabadi, Bahar (Co-Advisor)
Abstract
The urine formation and excretion system has long been of interest for mathematicians and physiologists to elucidate the obscurities within the process happen in renal tissue. In this study, a novel and absolutely three-dimensional approach is utilized for modeling urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of tubule's architecture revealed in anatomic studies and physiological literature. Since nephrons and vasculatures work interdependently through a highly structured arrangement in outer medulla which is dominated by vascular bundles, a highly detailed functional unit is proposed and also it is strongly justified...
Simulation of Urine Concentrating Mechanism in Rat Kidney Inner Medulla
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
Physicians use charts that are prepared by experiments on animals or humans to prescribe drug dosage for patients. This method requires much more time by the Ministry of Health to approve new drugs to be used in health-care centers. Furthermore،we have no sight on how a specific drug is going to be diffuse in our body. In order to predict the distribution of a drug or any minerals in the kidney we need to model it. The first step would be modeling the important species that influence the urine concentrating mechanism. Due to the complications in modeling that mechanism especially in the inner medulla zone، we hadn’t solid information regarding that area. It is about half a century that...
Urine concentrating mechanism modelling in rat kidney inner medulla
, Article 2016 23rd Iranian Conference on Biomedical Engineering and 2016 1st International Iranian Conference on Biomedical Engineering, ICBME 2016, 23 November 2016 through 25 November 2016 ; 2017 , Pages 111-116 ; 9781509034529 (ISBN) ; Saidi, M. S ; Banazadeh, M. H ; Sharif University of Technology
Abstract
Physicians use charts that are prepared by experiments on animals or humans to prescribe drug dosage for patients. This method requires some precious amount of time by the Ministry of Health to approve new drugs to be used in healthcare centers. Three-dimensional modeling of the inner medulla by considering the known physiological features help us to predict the distribution of a drug or any minerals in the kidney. In this study we present modeling of the important species distribution including Na+ and urea in the rat inner medulla that influence the urine concentrating mechanism. We use a C++ code to develop the inner medulla geometry based on physiological data to better capture the...
Three-dimensional simulation of urine concentrating mechanism in a functional unit of rat outer medulla. I. Model structure and base case results
, Article Mathematical Biosciences ; Vol. 258 , 2014 , pp. 44-56 ; ISSN: 00255564 ; Saidi, M. S ; Saadatmand, M ; Banazadeh, M. H ; Firoozabadi, B ; Sharif University of Technology
Abstract
The urine formation and excretion system have long been of interest for mathematicians and physiologists to elucidate the obscurities within the process happens in renal tissue. In this study, a novel three-dimensional approach is utilized for modeling the urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of tubule's architecture revealed in anatomic studies and physiological literature. Since nephrons and vasculatures work interdependently through a highly structured arrangement in outer medulla which is dominated by vascular bundles, a detailed functional unit is proposed based on this specific configuration....