Loading...
Search for:
uunclassified-drug
0.005 seconds
Trace determination of free formaldehyde in DTP and DT vaccines and diphtheria-tetanus antigen by single drop microextraction and gas chromatography-mass spectrometry
, Article Journal of Pharmaceutical and Biomedical Analysis ; Volume 50, Issue 3 , 2009 , Pages 287-292 ; 07317085 (ISSN) ; Ghambarian, M ; Salemi, A ; Es Haghi, A ; Sharif University of Technology
2009
Abstract
An immersed single drop microextraction (SDME) method was successfully developed for the trace enrichment of formaldehyde from DTP and DT vaccines and diphtheria-tetanus antigen. The formaldehyde was derivatized by means of the Hantzsch reaction. The dehydropyridine derivative was extracted into a microdrop of chloroform that suspended in a 4 ml sample solution for a preset time. The microdrop was then retracted into the microsyringe and injected directly into a gas chromatography-mass spectrometry (GC-MS) injection port. Effects of different parameters such as the type of solvent, extraction time, stirring rate, and temperature were studied and optimized. The limit of detection was 0.22...
Bottom-up synthesis of nitrogen and oxygen co-decorated carbon quantum dots with enhanced DNA plasmid expression
, Article Colloids and Surfaces B: Biointerfaces ; Volume 184 , 2019 ; 09277765 (ISSN) ; Khezri, J ; Esfandiari, S ; Mahdavi, H ; Karkhane, A. A ; Rahighi, R ; Heidarimoghadam, R ; Tayebi, L ; Hashemi, E ; Farmany, A ; Sharif University of Technology
Elsevier B.V
2019
Abstract
In this paper, a bottom-up hydrothermal route is reported for the synthesis of oxygen and nitrogen co-decorated carbon quantum dots (CQDs) using ammonium hydrogen citrate (AHC) as a single precursor. DLS data approved the formation of 4.0 nm (average size) CQDs. XRD pattern shows the interlayer spacing (002) of 3.5 Å for CQDs, which is exactly the same as that of crystalline graphite. XPS and FTIR spectra verified the formation of oxygen and nitrogen functional groups on the CQDs surface. Co-decorated carboxyl, hydroxyl and amine groups on the CQDs surfaces make them as promising polyelectrolyte for gene delivery. Toxicity assay showed a survival rate of 70% under different incubation times...