Loading...
Search for:
uv-vis-spectrometer
0.007 seconds
Synthesis of folate-modified, polyethylene glycol-functionalized gold nanoparticles for targeted drug delivery
, Article Journal of Dispersion Science and Technology ; Volume 31, Issue 4 , 2010 , Pages 492-500 ; 01932691 (ISSN) ; Vosoughi, M ; Alamzadeh, I ; Tavakoli, A ; Sharif University of Technology
Abstract
The chemical synthesis and in vitro drug delivery response of folate-modified, polyethylene glycol-functionalized gold nanoparticles were studied. Lysine-capped gold nanoparticles were first prepared. Subsequently, the widely used anticancer agent doxorubicin (DOX) was successfully attached to the surface of folate-modified, polyethylene glycol-functionalized gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to confirm the functionalization and conjugation steps in the chemical synthesis. The DOX-loading efficiency determined by UV-vis spectrometer was 80%. Drug release experiments displayed a controlled-release behavior...