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vancomycin-antibiotic
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Surface Modification of Metallic Implants and Improvement of their Biological Properties in Presence of Bioactive Ceramic Nanoparticles
, M.Sc. Thesis Sharif University of Technology ; Sadrnezhad, Khatiboleslam (Supervisor)
Abstract
By consideration of increasing demands to use implants and efforts to get technical knowledge and localization of this implants, considerable research in this field is needed. Therefore, presentation of a coating which is able to provide parameters needed for an acceptable implant is the aim of this study. In this direction, modification of surface of metallic implants in order to achieve nanotubes of titanium oxide, with the purpose of providing biocompatibility was done. On the other hand, because chronic infection of the implant’s surrounding is one of the main important reasons in rejection of implants, 〖TiO〗_2 nanotubes as a drug carrier were used in order to solve this problem. So,...
Kineticts of formation of Titania Nanotubes and Silk Fibroin on Titanium-based Metal for Investigating the Drug Release Behavior
, M.Sc. Thesis Sharif University of Technology ; Sadrnezhad, Khatiboleslam (Supervisor)
Abstract
In recent decades, due to the significant growth of implants’ application and considering the infection of the implants as the most momentous factor in implantation failure, study on the controlled drug release and other biologically active agents in modern drug delivery systems has attracted many kinds of research throughout the world and efforts are being made to use regulated drug delivery systems for implantation which is also the purpose of this current scientific work.To achieve this, the anodizing process was used to fabricate titanium oxide nanotubes (TNTs) to increase the absorption capacity of the drug in the implants and these TNTs were formed regularly and uniformly in an organic...
Experimental Study and Prediction of Vancomycin Partitioningin Surfactant-Salt Aqueous Two-Phase Systems
, M.Sc. Thesis Sharif University of Technology ; Vosughi, Manouchehr (Supervisor) ; Rashtchian, Davood (Supervisor) ; Pazuki, Gholamreza (Supervisor)
Abstract
In the past years, upstream processes have been receiving a considerable R&D investment and commercial attention. The downstream processes have, however, been overlooked causing a production bottleneck that is shifting the costs of production from up to downstream. The need to develop more efficient and cost-effective separation and purification processes is, thus, crucial in order to improve process efficiency and economics keeping the required high standards of quality for market approval. In this research, promising aqueous two-phase systems (ATPS) containing Tween 20 as a quite biocompatible non-ionic surfactant and different salts (K3Citrate and NaH2PO4) were prepared and their...
Bioactive Nanocomposite Coatings Containing Anti-Bacterial Factors with Controlled Release on the Bone Implant
, Ph.D. Dissertation Sharif University of Technology ; Ghorbani, Mohammad (Supervisor) ; Shokrgozar, Mohammad Ali (Supervisor) ; Pooshang Bagheri, Kamran (Co-Supervisor)
Abstract
Aseptic loosening and infection are two major problems of bone implants. Aseptic loosening occurs due to poor cell growth and poor adhesion to the implant surface over time. Bone infection at the implant site occurs mainly by the staphylococcus aureus bacteria. In some cases, infection occurs in the short term and in the early times after implantation, and in some cases, infection occurs in later times. The aim of this study is to synthesize and evaluate antibacterial coatings, while having cell growth-promoting components and cell differentiation to solve bone implant problems simultaneously. Also, the issue of bacterial resistance to antibiotics and their risks in bone implants is another...
Electrophoretic encapsulation for slow release of vancomycin from perpendicular TiO2 nanotubes grown on Ti6Al4V electrodes
, Article Materials Research Express ; Volume 6, Issue 12 , 2019 ; 20531591 (ISSN) ; https://iopscience.iop.org/article/10.1088/2053-1591/ab6c98 ; Ahmadi Seyedkhani, S ; Sadrnezhaad, S. K ; Sharif University of Technology
Institute of Physics Publishing
2019
Abstract
Ordered perpendicular TiO2 nanotubes (TNT) with 405 to 952 nm length and 60 to 90 nm diameter were grown via 40 to 120 min anodization of Ti6Al4V flat substrates. The samples were called TNT-40, -60, -80, -100, and -120. Vancomycin was loaded on the bare and anodized electrodes by separate immersion and electrophoretic (EP) deposition procedures. EP loading resulted in storage capacity of 5221.86 μg cm-2 for TNT-80 which was much higher than 1036.75 μg cm-2 of immersed sample. Drug release comprised of three stages: (i) burst release (78% for the bare, and 23% for the TNT-80 sample), (ii) gradual transport (21% for the bare, and 64% for the TNT-80 sample), and (iii) equilibrium. Transfer...
Electrophoretic encapsulation for slow release of vancomycin from perpendicular TiO2 nanotubes grown on Ti6Al4V electrodes
, Article Materials Research Express ; Volume 6, Issue 12 , 2019 ; 20531591 (ISSN) ; Ahmadi Seyedkhani, S ; Sadrnezhaad, S. K ; Sharif University of Technology
Institute of Physics Publishing
2019
Abstract
Ordered perpendicular TiO2 nanotubes (TNT) with 405 to 952 nm length and 60 to 90 nm diameter were grown via 40 to 120 min anodization of Ti6Al4V flat substrates. The samples were called TNT-40, -60, -80, -100, and -120. Vancomycin was loaded on the bare and anodized electrodes by separate immersion and electrophoretic (EP) deposition procedures. EP loading resulted in storage capacity of 5221.86 μg cm-2 for TNT-80 which was much higher than 1036.75 μg cm-2 of immersed sample. Drug release comprised of three stages: (i) burst release (78% for the bare, and 23% for the TNT-80 sample), (ii) gradual transport (21% for the bare, and 64% for the TNT-80 sample), and (iii) equilibrium. Transfer...