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    MicroRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

    , Article Future Virology ; Volume 13, Issue 9 , 2018 , Pages 637-645 ; 17460794 (ISSN) Moghoofei, M ; Bokharaei Salim, F ; Esghaei, M ; Keyvani, H ; Honardoost, M ; Mostafaei, S ; Ghasemi, A ; Tavakoli, A ; Javanmard, D ; Babaei, F ; Garshasbi, S ; Monavari, S. H ; Sharif University of Technology
    Abstract
    Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV-1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with healthy controls (p < 0.001 for all comparisons). Conclusion: The mentioned miRNAs seem to influence the clinical progression of HIV-1 infection in naive patients. Moreover, determining the profiles of... 

    Design of an effective piezoelectric microcantilever biosensor for rapid detection of COVID-19

    , Article Journal of Medical Engineering and Technology ; Volume 45, Issue 6 , 2021 , Pages 423-433 ; 03091902 (ISSN) Kabir, H ; Merati, M ; Abdekhodaie, M. J ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    Acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called COVID-19, is one of the most contagious viruses resulting in a progressive pandemic. Since specific antiviral treatments have not been developed yet and its fatal rate is almost high, early and fast detection is critical for controlling the outbreak. In this study, a piezoelectric microcantilever biosensor has been designed for detecting COVID-19 samples directly without requiring preparation steps. The biosensor acts as a transducer and is coated with the related antibody. When the SARS-CoV-2 antigens adsorbed on the microcantilever top surface through their spike proteins, a surface stress due to the mass change would be...