Sharif Digital Repository

Today, commercial CFD codes are widely used to simulate many different entry flow problems. The flow in the developing zone undergoes a transition from a specified velocity profile at the inlet section to a fully developed profile in the region far from the inlet. Previous investigations have shown that the hydrodynamic variables, such as velocity and pressure magnitudes, along the centreline converge to a mesh independent solution even when coarse grid distributions are utilised. However, the present work shows that the local velocity profile is highly dependent on grid resolution in the vicinity of solid boundaries. It is shown that failure to account for the grid resolution can result in... 

Introduction: Endothelial cells (ECs) morphology strongly depends on the imposed mechanical stimuli. These mechanical stimuli include wall shear stress (WSS) and biaxial cyclic stretches (CS). Under combined loading, the effect of CS is not as simple as pure CS. The present study investigates the morphological response of ECs to the realistic mechanical stimuli. Methods: The cell population is theoretically studied using our previous validated model. The mechanical stimuli on ECs are described using four parameters; WSS magnitude (0 to 2.0 Pa), WSS angle (− 50° to 50°), and biaxial CS in two perpendicular directions (0 to 10%). The morphology of ECs is reported using four parameters; average... 

A new technique for the laminar-turbulent intermittency measurement based on the surface hot-film data is presented. The existing techniques require data acquired from the calibrated hot-films which leads to the real wall shear stress values. However, calibration of the hot-films is usually very complex. In the proposed method, a technique based on the probability distribution function (PDF) of the acquired data using the uncalibrated hot-film sensors is presented and evaluated. The PDF is prepared for a reduced form of the quasi-wall shear stress value instead of the real shear stress value one. This leads to a standard normal distribution curve for the PDF in the turbulent flow region and... 

Nitric Oxide (NO) provides myocardial oxygen demands of the heart during exercise and cardiac pacing and also prevents cardiovascular diseases such as atherosclerosis and platelet adhesion and aggregation. However, the direct in vivo measurement of NO in coronary arteries is still challenging. To address this matter, a mathematical model of dynamic changes of calcium and NO concentration in the coronary artery was developed for the first time. The model is able to simulate the effect of NO release in coronary arteries and its impact on the hemodynamics of the coronary arterial tree and also to investigate the vasodilation effects of arteries during cardiac pacing. For these purposes, flow... 

Atherosclerosis as a common cardiovascular disease is a result of both adverse hemodynamics conditions and monocyte deposition within coronary arteries. It is known that the adhesion of monocytes on the arterial wall and their interaction with the vascular surface are one of the main parameters in the initiation and progression of atherosclerosis. In this work, hemodynamic parameters and monocyte deposition have been investigated in a 3D computational model of the Left Anterior Descending coronary artery (LAD) and its first diagonal branch (D1) under the heart motion. A one-way Lagrangian approach is performed to trace the monocyte particles under different blood flow regimes and heart motion... 

Cardiovascular diseases are one of the major causes of death in the world; atherosclerosis being one aspect. Carotid bifurcation is one of the sites that are vulnerable to this disease. Wall Shear Stress (WSS) is known to be responsible for the process of atherogenesis. In this study, we have simulated the blood flow for Newtonian and non-Newtonian, steady and unsteady, flow conditions in three idealistic and five realistic geometries. A risk factor has been presented based on the results of wall shear stress and, then, a relation was found between geometrical features and the wall shear stress risk factor. Our main conclusions are: 1) The non-Newtonian behavior of blood elevates the value... 

The function and morphology of Endothelial Cells (ECs) play a key role in atherosclerosis. The mechanical stimuli of ECs, such as Wall Shear Stress (WSS) and arterial wall strain, greatly inuence the function and morphology of these cells. The present article deals with computations of these stimuli for a 3D model of a healthy coronary artery bifurcation. The focus of the study is to propose an accurate method for computations of WSS and strains. Two approaches are considered: Coupled simultaneous simulation of arterial wall and blood flow, called fluid-Structure Interaction (FSI) simulation, and decoupled, which simulates each domain (fluid and solid domain) separately. The study... 

Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall. In this research, a multilayer Fluid-Structure Interaction (FSI) model is studied to simulate the penetration... 

LDL concentration is believed to be responsible for plaque formation that leads to atherosclerotic cardiovascular disease. We conducted this study to investigate the effects of hematocrits and LDL diameters on LDL concentration on the wall of an abdominal aortic aneurysm (AAA). The blood flow was considered to be a pulsatile and non-Newtonian flow whose viscosity was a function of hematocrits and strain rate. Lumen, Brownian, and thermophoresis diffusions were analyzed in LDL concentration. The results demonstrated that adding thermophoresis diffusion increases LDL concentration. Moreover, among three types of LDLs, including small LDLs, intermediate LDLs, and large LDLs, small LDLs were the... 

In an experimental study, investigation is performed based on the surface-mounted hot-film sensors and surface pressure and rake pressure measurements. The boundary-layer (BL) events such as laminar separation (LS), transition onsets, and variations of the wall shear stress are discussed and compared for both pitching and plunging oscillations for various cases of before, within, and beyond the static stall angle of attack (AOA) conditions. All experiments are conducted in a low-speed wind tunnel. The surface pressures are measured using differential pressure sensors with a range from 0.075 to 1.0 psi and with a maximum error of 0.15% of their full span. In addition, the wake profile behind... 

LDL concentration is believed to be responsible for plaque formation that leads to atherosclerotic cardiovascular disease. We conducted this study to investigate the effects of hematocrits and LDL diameters on LDL concentration on the wall of an abdominal aortic aneurysm (AAA). The blood flow was considered to be a pulsatile and non-Newtonian flow whose viscosity was a function of hematocrits and strain rate. Lumen, Brownian, and thermophoresis diffusions were analyzed in LDL concentration. The results demonstrated that adding thermophoresis diffusion increases LDL concentration. Moreover, among three types of LDLs, including small LDLs, intermediate LDLs, and large LDLs, small LDLs were the... 

In an experimental study, investigation is performed based on the surface-mounted hot-film sensors and surface pressure and rake pressure measurements. The boundary-layer (BL) events such as laminar separation (LS), transition onsets, and variations of the wall shear stress are discussed and compared for both pitching and plunging oscillations for various cases of before, within, and beyond the static stall angle of attack (AOA) conditions. All experiments are conducted in a low-speed wind tunnel. The surface pressures are measured using differential pressure sensors with a range from 0.075 to 1.0 psi and with a maximum error of 0.15% of their full span. In addition, the wake profile behind... 

This paper addresses the problem of aerothermoelastic behavior of a flat skin panel with wall shear stress effect in high supersonic flow. A fully coupled high-supersonic skin panel model that accounts for all thermal-fluid-structure interactions is developed. The governing equations are based on the von Kármán large deflection of Isotropic flat plates. Viscous and inviscid aerothermoelastic loading mechanisms between the fluid and structure are considered. The lumped-capacity assumption and Duhamel superposition principle are used for heat communication analysis. In addition, the effects of viscous flow shear stress, static pressure differential over the external surface, and constant axial...