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Toward epileptic brain region detection based on magnetic nanoparticle patterning
, Article Sensors (Switzerland) ; Volume 15, Issue 9 , September , 2015 , Pages 24409-24427 ; 14248220 (ISSN) ; Shamloo, A ; Alasty, A ; Ghafar Zadeh, E ; Sharif University of Technology
MDPI AG
2015
Abstract
Resection of the epilepsy foci is the best treatment for more than 15% of epileptic patients or 50% of patients who are refractory to all forms of medical treatment. Accurate mapping of the locations of epileptic neuronal networks can result in the complete resection of epileptic foci. Even though currently electroencephalography is the best technique for mapping the epileptic focus, it cannot define the boundary of epilepsy that accurately. Herein we put forward a new accurate brain mapping technique using superparamagnetic nanoparticles (SPMNs). The main hypothesis in this new approach is the creation of super-paramagnetic aggregates in the epileptic foci due to high electrical and...
Superparamagnetic nanoparticles for epilepsy detection
, Article World Congress on Medical Physics and Biomedical Engineering, 2015, 7 June 2015 through 12 June 2015 ; Volume 51 , June , 2015 , Pages 1237-1240 ; 16800737 (ISSN) ; 9783319193878 (ISBN) ; Shamloo, A ; Alasty, A ; Ghafar Zadeh, E ; Jaffray D. A ; Sharif University of Technology
Springer Verlag
2015
Abstract
Epilepsy is the most common neurological disorder that is known with uncontrolled seizure. Around 30% of patients with epilepsy resist to all forms of medical treatments and therefore, the removal of epileptic brain tissue is the only solution to get these patients free from chronical seizures. The precise detection of an epileptic zone is key to its treatment. In this paper, we propose a method of epilepsy detection using brain magnetic field. The possibility of superparamagnetic nanoparticle (SPMN) as sensors for the detection of the epileptic area inside the brain is investigated. The aggregation of nanoparticles in the weak magnetic field of epileptic brain is modeled using potential...