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zinc-ferrite-spinels
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Zinc ferrite spinel-graphene in magneto-photothermal therapy of cancer
, Article Journal of Materials Chemistry B ; Vol. 2, Issue. 21 , 2014 , p. 3306-3314 ; Meidanchi, A ; Ghaderi, E ; Khoei, S ; Sharif University of Technology
Abstract
A magneto-photothermal therapy for cancer (in vitro photothermal therapy of prostate cancer cells and in vivo photothermal therapy of human glioblastoma tumors in the presence of an external magnetic field) was developed using superparamagnetic zinc ferrite spinel (ZnFe2O4)-reduced graphene oxide (rGO) nanostructures (with various graphene contents). In vitro application of a low concentration (10 μg mL-1) of the ZnFe 2O4-rGO (20 wt%) nanostructures under a short time period (∼1 min) of near-infrared (NIR) irradiation (with a laser power of 7.5 W cm-2) resulted in an excellent destruction of the prostate cancer cells, in the presence of a magnetic field (∼1 Tesla) used for localizing the...
Hyperthermia-induced protein corona improves the therapeutic effects of zinc ferrite spinel-graphene sheets against cancer
, Article RSC Advances ; Vol. 4, issue. 107 , 2014 , p. 62557-62565 ; Akhavan, O ; Meidanchi, A ; Laurent, S ; Mahmoudi, M ; Sharif University of Technology
Abstract
Superparamagnetic zinc ferrite spinel-graphene nanostructures were synthesized as potential therapeutic agents in the magnetic targeted photothermal therapy of cancer and/or drug delivery. The global temperature of the solution and the local temperature at the nanoparticle (NP) surface determine the protein corona composition/content, which in turn affects the biological effects of NPs and the corresponding physiological responses. Therefore, it is rational to hypothesize that spinel-graphene nanostructures may have distinct protein corona compositions and contents, and therapeutic and toxic effects under laser irradiation. To assess this hypothesis, the effects of laser irradiation on the...
ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells
, Article Materials Science and Engineering C ; Volume 46 , January , 2015 , Pages 394-399 ; 09284931 (ISSN) ; Akhavan, O ; Khoei, S ; Shokri, A. A ; Hajikarimi, Z ; Khansari, N ; Sharif University of Technology
Elsevier Ltd
2015
Abstract
Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g., ~ 1 min for 2 mg mL- 1 of the nanoparticles in ethanol) by applying an external magnetic field (~ 1 T). The ZnFe2O4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high...