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α-hydroxyphosphonates
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A novel procedure for conversion of epoxides to α -hydroxyphosphonates with a trialkylphosphite mediated by LiClO4
, Article Tetrahedron Letters ; Volume 44, Issue 43 , 2003 , Pages 7933-7935 ; 00404039 (ISSN) ; Saidi, M. R ; Sharif University of Technology
Elsevier Ltd
2003
Abstract
A new method has been developed for the direct conversion of epoxides to α-hydroxyphosphonates by the reaction of a trialkylphosphite with the epoxide in 5 M lithium perchlorate in diethyl ether (LPDE). The reaction is highly regioselective and efficient with excellent yields under mild and neutral conditions. © 2003 Published by Elsevier Ltd