Synthesis of Amino Acids Schiff Base Complexes of Gadolinium and Study of Their Interaction with BSA, M.Sc. Thesis Sharif University of Technology ; Mohammadi Boghaei, Davar (Supervisor)
Abstract
Salicylaldehyde-amino acid Schiff base complexes are used as non-enzymatic models for the metal-pyridoxal (Vitamin B6) amino acid Schiff base systems which are key intermediates in many metabolic reactions of amino acids catalyzed by enzymes which require pyridoxal as a cofactor (transamination, decarboxylation, α and β elimination, racemization, etc.). In addition, complexes of amino acid Schiff bases are considered to constitute new kinds of potential anticancer, antitumor, antiradical and antibacterial reagents. On the other hand nuclear magnetic resonance imaging (MRI), has become a powerful tool for clinical diagnostics thanks to the development of a new class of pharmaceuticals...
Cataloging briefSynthesis of Amino Acids Schiff Base Complexes of Gadolinium and Study of Their Interaction with BSA, M.Sc. Thesis Sharif University of Technology ; Mohammadi Boghaei, Davar (Supervisor)
Abstract
Salicylaldehyde-amino acid Schiff base complexes are used as non-enzymatic models for the metal-pyridoxal (Vitamin B6) amino acid Schiff base systems which are key intermediates in many metabolic reactions of amino acids catalyzed by enzymes which require pyridoxal as a cofactor (transamination, decarboxylation, α and β elimination, racemization, etc.). In addition, complexes of amino acid Schiff bases are considered to constitute new kinds of potential anticancer, antitumor, antiradical and antibacterial reagents. On the other hand nuclear magnetic resonance imaging (MRI), has become a powerful tool for clinical diagnostics thanks to the development of a new class of pharmaceuticals...
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