Over 10-b On-Chip Impedance Measurement System for High Frequency Range

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Mirjalili, Ramin | 2009

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 39722 (05)
University: Sharif University of Technology
Department: Electrical Engineering
Advisor(s): Atarodi, Mojtaba; Mehrani, Khashayar
Abstract:
Diabetes is one of the most catastrophic diseases in the world. There will be an end to patients’ problems if scientists can invent the artificial pancreas, but there is no implantable sensing core available. All of the sensors used for measuring blood glucose level were based on an electrochemical sensor which will generate a glucose level dependent electric current. The chemical structure of that sensor will deny its usability for in vivo applications. By exploring several biological and electrical literatures we introduced a fully electrical method for sensing the blood glucose level by impedance measurement. In this thesis we introduced a new method for sensing the blood glucose variation through measuring the permittivity coefficient of blood at 1GHz frequency. This method will be used in an on-chip impedance spectroscope system for fully electrical blood glucose concentration measurement. This system will be presented as my partner’s thesis. The IS system will extract the blood glucose concentration data by measuring the impedance variation and more importantly the imaginary part of impedance-capacitive portion.
Keywords:
Impedance Spectroscopy ; Complementary Metal Oxide Semiconductor Technology (CMOS) ; Biosensor ; Microfluidic System ; Tissue Electric Behavior

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