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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 39967 (05)
- University: Sharif University of Technology
- Department: Electrical Engineering
- Advisor(s): Zahedi, Edmond
- Abstract:
- In this thesis, a cellular model of electroporation process and its detection by ultrasound signals is proposed. Electroporation is permeabilization of the cell membrane, caused by an external electric field. The resulted pores open cell’s membrane to large or hydrophilic molecules. The process of Electroporation has been used in Gene therapy and treatment of solid tumors. In this project, first we made a phantom of electroporated tissue and a phantom of normal tissue and then we simulated their responses to a linear array ultrasound transducer. By comparision of received signals from phantoms the probable effect of electroporation on ultrasound RF signals revealed. Results show up to 5 % change in signals energy between normal and electroporated tissue phantoms when the transducer frequency 16 MHz and 3.5 % change with frequency of 8 MHz. in addition, there are no obvious difference (less than 2%) between signals with transducer frequency of 2 and 4 MHz. These results are expected to be used as an indication of electroporation’s effect on cells. We also simulated the effects of tissue motions in response to capilary’s pressure, inspiration and also motion artifacts of electroporation process. Results indicate that motion artifact has a considarable effect (more than 10 percent difference in signal’s energy between motion phantom and normal phantom) which is higher than electroporation effect
- Keywords:
- Ultrasonic Waves ; Electroporation ; Solid Tumors
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