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Modeling of Aerosol Transport in Human Lung

Ghasemi, Hosssein | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 40263 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Saeedi, Mohammad Saeed; Firoozabadi, Bahar
  7. Abstract:
  8. This thesis is concerned with modeling of air flow through upper airways of the human lung. Mechanisms of fresh (high Oxygen density) air transportation toward deep lung airways and Alveoli and reverse transport of dirty (low Oxygen density) air to upper airways of lung and moth, particle transport and deposition process, parameters affecting the simulation of flow like: steady and transient simulation, type of geometry including planar and non-planar, structured and unstructured network of airways, respiration pattern and real cycle of inspiration and expiration, inspection of expiration cycle on particle absorption efficiency and other effective parameters in deposition of particles in lung are the other aspects of current study. In conclusion this work investigates effect of different parameters on the accuracy of results in lung particle absorption problems, and with the help of that aims to identify the foundations for accurate simulation of particle absorption in lung. As a follow up the problems of lung particle transport can be inspected with great accuracy. Investigating effect of steady and unsteady solution on flow pattern and absorption efficiency, search for relation between the steady and unsteady flow of respiration and finding the absorption efficiency of the second generation Horsfield airways are the other aspects of the current work. FLUENT software is used for the simulation purpose and for particles tracking the available code has been developed. This code uses the results of flow from FLUENT to track particles.

  9. Keywords:
  10. Fluent Software ; Aerosol Transport ; Upper Human Lung ; Fresh Air Transfer Mechanism ; Weible Model ; Horsfiled Model

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