Michael Addition of Aromatic Amines and Synthesis Some Derivatives of Thiomorpholins

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Hosseyni, Morteza | 2010

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 41687 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Mahmoudi Hashemi, Mohammad; Ziyaei Halimehjani, Azim
Abstract:
This project investigates on synthesis of β-amino carbonyl compounds with new approach to become closer to green chemistry principals.In this project, we investigated the synthesis of β-amino carbonyl compounds with aromatic amines and electron deficient alkenes in the Michael reaction using boric acid and glycerol in water as a green media. High yields of the products and easy handling are some advantages of this procedure. Also, we investigated the Michael reaction in different solvents and temperatures but gave better results in the aqueous media. Moreover, thiomorpholine derivatives were synthesized using this method to give excellent yield.
Keywords:
Michael Reaction ; Amines ; B-Aminocarbonyls ; Boric Acid/Glyserol ; Thiomorpholine

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