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Study the Effect of Considering two Layered wall for Carotid Artery Bifurcation on Distribution of Hemodynamic and Non-Hemodynamic Parameters using a Fluid-Structure Interaction Method

Nikparto, Ali | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 41785 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Dehghan Firoozabadi, Bahar; Saidi, Mohammad Said
  7. Abstract:
  8. It is known today that arterial diseases are among the leading cause of death in modern societies. More than 50% of deaths in western countries are mainly occurred as results of these diseases, namely atherosclerosis. In order to study risk factors and to understand the full process of how arterial diseases initiate and progress, many research topics have been introduced and studied. Researchers believe that mechanical factors such as Wall Shear Stress (WSS), Pressure distribution, Cyclic strain, Back flow zones and many other factors are responsible for initiation of atherosclerosis. Different patterns of Wall Shear Stress and Strain are seen in arteries. Among other factors outlined in literature, geometry, transport properties of blood and mechanical behavior of wall are said to have influence on gene expression that can finally lead to atherosclerosis. To date many studies have been performed to describe the local hemodynamic and its role on atherosclerosis.
    In this study, the finite element method (FEM) was applied to simulate the physiologic circumferential strain/stress in the carotid bifurcation by the use of CFD modeling results as the boundary conditions. A fully-coupled fluid–structure interaction (FSI) analysis was applied in order to test, examine and study the following factors. The effect of considering compliance for walls and generalizing the developed model to a more accurate model by considering 2 layered nature of the arterial wall.
    The results show that though considering multi-layered nature of the wall does not have significant effect on distribution of hemodynamic parameters, but it has a very high influence on non-hemodynamic parameters such as stress and strain that can enhance gene-expression of EC cells. Thus it is merely as important as choosing the right model to describe the transport properties of blood
  9. Keywords:
  10. Computational Fluid Dynamics (CFD) ; Wall Shear Stress (WSS) ; Carotid Bifurcation ; Fluid-Solid Interaction

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