Spectrophotometric Determination of Glutathione and Cysteine Based on Aggregation of Colloidal Gold Nanoparticles, M.Sc. Thesis Sharif University of Technology ; Hormozi Nezhad, Mohammad Reza (Supervisor)
Abstract
low-molecular-weigth aminothiols such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) play a critical role in many biochemical pathways . Their level in biological fluids such as human plasma and urine are important for clinical diagnostics of a variety of diseases.
We report herein the development of a highly sensitive colorimetric method for detection of cysteine and glutathione using the citrate capped gold nanoparticles (Au-NPs). This thiol containing molecules exhibit intriguing reactivities with Au nanoparticles. The reactivity involves the displacement of the citrate shell by the thiolate shell which is followed by intermolecular electrostatic interactions or... Cataloging briefSpectrophotometric Determination of Glutathione and Cysteine Based on Aggregation of Colloidal Gold Nanoparticles, M.Sc. Thesis Sharif University of Technology ; Hormozi Nezhad, Mohammad Reza (Supervisor)
Abstract
low-molecular-weigth aminothiols such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) play a critical role in many biochemical pathways . Their level in biological fluids such as human plasma and urine are important for clinical diagnostics of a variety of diseases.
We report herein the development of a highly sensitive colorimetric method for detection of cysteine and glutathione using the citrate capped gold nanoparticles (Au-NPs). This thiol containing molecules exhibit intriguing reactivities with Au nanoparticles. The reactivity involves the displacement of the citrate shell by the thiolate shell which is followed by intermolecular electrostatic interactions or... Find in contentBookmark |
|