Transient Diffusion of Drugs into the Intervertebral Disc using Finite Element Method

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Motaghinasab, Samira | 2011

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 42209 (08)
University: Sharif University of Technology
Department: Mechanical Engineering
Advisor(s): Parnianpour, Mohammad; Hoviattalab, Maryam; Shirazi Adl, Abolfazl
Abstract:
In this study, transient diffusion of drug into the intervertebral disc is considered. The amount of Diffused drug from the blood into the intervertebral disc of dog is measured and concentration of drug is calculated for each region of the intervertebral disc including nucleus pulpous, inner annulus fibroses and outer annulus fibroses. Using finite element method, it is shown that the amount of drug diffusion into the intervertebral disc is affected by some parameters such as the type of drug, dose if drug and endplate calcification. This research is done in two parts: In first part, diffusion of drug (sulphate) into the dog intervertebral disc is investigated to compare the obtained results with experimental ones in order to verify the procedure and accuracy of the simulation. In second part which is the main section of the study and its result is so significant clinically, diffusion of drug (cephazolin) into the human intervertebral disc is modeled and simulated and using MRI studies, drug diffusion into the disc is considered and the role of effective parameters has been investigated.
Keywords:
Finite Element Method ; Intervertebral Disc ; Drug Diffusion ; Cephazoline

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