Transient Diffusion of Drugs into the Intervertebral Disc using Finite Element Method, M.Sc. Thesis Sharif University of Technology ; Parnianpour, Mohammad (Supervisor) ; Hoviattalab, Maryam (Supervisor) ; Shirazi Adl, Abolfazl (Co-Advisor)
Abstract
In this study, transient diffusion of drug into the intervertebral disc is considered. The amount of Diffused drug from the blood into the intervertebral disc of dog is measured and concentration of drug is calculated for each region of the intervertebral disc including nucleus pulpous, inner annulus fibroses and outer annulus fibroses. Using finite element method, it is shown that the amount of drug diffusion into the intervertebral disc is affected by some parameters such as the type of drug, dose if drug and endplate calcification. This research is done in two parts: In first part, diffusion of drug (sulphate) into the dog intervertebral disc is investigated to compare the obtained...
Cataloging briefTransient Diffusion of Drugs into the Intervertebral Disc using Finite Element Method, M.Sc. Thesis Sharif University of Technology ; Parnianpour, Mohammad (Supervisor) ; Hoviattalab, Maryam (Supervisor) ; Shirazi Adl, Abolfazl (Co-Advisor)
Abstract
In this study, transient diffusion of drug into the intervertebral disc is considered. The amount of Diffused drug from the blood into the intervertebral disc of dog is measured and concentration of drug is calculated for each region of the intervertebral disc including nucleus pulpous, inner annulus fibroses and outer annulus fibroses. Using finite element method, it is shown that the amount of drug diffusion into the intervertebral disc is affected by some parameters such as the type of drug, dose if drug and endplate calcification. This research is done in two parts: In first part, diffusion of drug (sulphate) into the dog intervertebral disc is investigated to compare the obtained...
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