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Evaluation of Mechanical and Structural Properties of Titanium Bone Scaffolds

Naddaf Dezfuli, Sina | 2011

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 42314 (07)
  4. University: Sharif University of Technology
  5. Department: Materials science and Engineering
  6. Advisor(s): Sadrnezhad, Khatiboleslam; Shokrgozaar, Mohammad Ali
  7. Abstract:
  8. Interconnected–pore titanium scaffolds were fabricated by sintering of compressed mixture of TiH1.924 and urea or NaCl. Urea was removed by evaporation during sintering and NaCl was removed with water. TiH1.924 was used to enhance gas evolution for perpetuation of foam formation. Morphological studies of the spacer-removed scaffolds showed that the spacer shapes were replicated to the pores. Minimization of stress concentration at walls of the pores was, hence, helped by utilization of the spacers with spherical particles. The scaffolds having relative densities of 0.34 to 0.65 consisted pores of 200 to 600 μm diameter, compression strengths of 51 to 260 MPa, Young’s modulus of 6.3 to 22.66 and hardness of 134 to 341 HV. STA analysis confirmed two-step decomposition of TiH1.924 when heated under nitrogen or argon. TiH1.924 oxidation was more substantial under nitrogen than argon. Based on XRD results, TiH1.924 decomposition was two-step under vacuum, too. In-vitro evaluations performed with the use of MTT assay, yielded the Alkaline phosphatase activity and alizarin red staining which occurred in flow perfusion bioreactor used to perform the cell culture. Observations revealed excellent attachment and proliferation of G-292 cells to the foamy scaffolds
  9. Keywords:
  10. Bone Scaffold ; Space Holder ; Biocompatibility ; Mechanical Test

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  • ارزيابي خواص مكانيكي و ساختاري داربست تيتانيمي توليد شده
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