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Developing a Roadmap for Whole Lung Modeling and Some of the Required Software

Sani Josheqani, Mahdi | 2011

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 41458 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Saeedi, Mohammad Saeed
  7. Abstract:
  8. In this work, a new methodology for modeling the whole lung using porous media is presented. Dealing with the details of the proposed method establishes the need for some tools. Proposed method combines data extraction from lung images to identify large airways, porosity and porous region boundaries. Combining some sequential images, change in properties with time could be obtained. To obtain behavior of this porous media with respect to flow, a method based on the classification of bifurcations and gas exchange areas and pore scale modeling of these classes is proposed. All these require a specifically designed numerical tool. Development of this tool is the subject of the next parts of this work. Bases of the numerical tool are discussed and the governing equations are discretized using cell-centered unstructured polyhedral grid collocated dynamic mesh finite volume method. Some innovations are added to the current literature, which reduce the computational cost. Considering problems imposed by outlet boundary conditions, a new open type boundary condition is developed and tested. New search algorithms which fit the computational requirements of the numerical code are developed next. Finally a new version of the immersed boundary method which is capable of modeling thin membranes is presented. In conclusion the current work proposes a new methodology for modeling the whole deforming lung. Applying the methodology requires some numerical tools. Some of these tools are developed and tested in this work
  9. Keywords:
  10. Lung ; Modeling ; Porous Media ; Search Algorithm ; Dynamic Mesh ; Immersed Boundary Method (IBM) ; Open Boundary Condition

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