Investigation of phase Solubility Enhancement of Paclitaxel by Inclusion Complex of drug in B-CD-g-PG, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Vossoughi, Manoochehr (Supervisor) ; Kazemi Daliri, Akhtarolmoluk (Supervisor)
Abstract
Paclitaxel is using as a drug against breast and ovary cancers. Although paclitaxel has high biologic activity, it has very poor solubility in water the same as some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites.
Beta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project, by adding polymeric polyglycerol branches on Beta-Cyclodextrin, a polymeric nanostructure has been developed to enhance water solubility in comparison with pure Beta-Cyclodextrin. Study on producing... Cataloging briefInvestigation of phase Solubility Enhancement of Paclitaxel by Inclusion Complex of drug in B-CD-g-PG, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Vossoughi, Manoochehr (Supervisor) ; Kazemi Daliri, Akhtarolmoluk (Supervisor)
Abstract
Paclitaxel is using as a drug against breast and ovary cancers. Although paclitaxel has high biologic activity, it has very poor solubility in water the same as some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites.
Beta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project, by adding polymeric polyglycerol branches on Beta-Cyclodextrin, a polymeric nanostructure has been developed to enhance water solubility in comparison with pure Beta-Cyclodextrin. Study on producing... Find in contentBookmark |
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