Application of Pd-Au Nanoparticles on Carbon Nanotubes Modified Electrode for Electrochemical Determination of Ceftazidime

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Salimian, Razieh | 2012

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 43926 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Shahrokhian, Saeed
Abstract:
This present work is an introduction of a new electrochemical sensor toward the determination of biomolecule. A simple electrodeposition method was employed to construct a thin film modifier of palladium–gold nanoparticles (Pd–AuNPs) decorated multi-walled carbon nanotube (MWCNT) on the surface of glassy carbon electrode (GCE). Morphological characterization of the modified electrode was performed by the scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and cyclic voltammetry (CV) techniques. This nanostructured film modified electrode effectively exhibited enhanced properties for the detection of ceftazidime (CFZ). The effects of various experimental variables such as, amounts of casted MWCNT, time and potential of deposition of metal nanoparticles and the pH of the buffered solution on the electrode response were optimized. The proposed electrode showed a linear dynamic range of 0.05–10 µM and 10–50 µM. This modified electrode was successfully supports the sensitive detection of trace amounts of CFZ in pharmaceutical and clinical preparations
Keywords:
Gold Nanoparticle ; Carbon Nanotubes ; Cyclic Voltammetry ; Palladium Nanoparticle ; Ceftazidime

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