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Manufacture & Design of a Programmable Micro Syringe for Injecting of Biodegradable Photo Polymers

Sheydaeian, Esmat | 2011

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 44249 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Durali, Mohammad; Toyserkani, Ehsan
  7. Abstract:
  8. The micro-scale channel creation in Osteochondral scaffolds is a prominent issue in tissue engineering. In this project we tried to identify the relevant parameters to obtain the method for injecting a biodegradable photo polymer to achieve a micro channel by predictable size.Due to inadequate accuracy in measuring the properties of the non –Newtonian working fluid, it was decided to use the Newtonian fluid equations in this study. The relevant equations for injecting the liquid under constant pressure were extracted. The modeling and design of micro syringe system was then completed. Using the made set up experiment to measure the fluid viscosity were performed.The next step was the identification of effective parameters and equations influencing the channel size. The working liquid was injected on a glass substrate in different geometrical condition of substrate slope and needle angle. This stage was a major goal of this project. The complexity of the equations and the lack of information about the fluid surface tension and static contact angle, as the effective liquid properties in this problem, were the main obstacles in reaching to an exact solution for this problem. To overcome this problem we used an experimental scheme and analyzed the shape of the liquid droplets on glass. A curve fitting method to estimate the channel shape was employed to complete the relation of the channel size with the other parameters like flow rate, substrate velocity and geometry. This analysis demonstrated that the appropriate fitness with the minimal errors result from polynomial in 2nd and 4th orders. To evaluate the results under insufficient accuracy in measuring the material properties made us to perform a sensitivity analysis.The results showed a better adjustment with our hypothesis to consider a 2nd order polynomial function for predicting the channel shape. In addition this shape of function results a lower sensitivity to inaccuracies in viscosity measurements
  9. Keywords:
  10. Modeling ; Biodegradable Photo Polymer ; Material Physical Properties Measuring ; Precise Liquid Injection ; Channel Size and Shape

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