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| 2013

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 44552 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Matloubi Moghaddam, Firouz
Abstract:
Fused pyrimidines have attracted considerable attention recently in synthetic organic chemistry because of their wide range of biological activities pharmaceutical, therapeutic properties, antibacterial, antiviral, antitumor, and anti-inflammatory activities. We have reported a new and efficient synthesis of dihydro and tetrahydro pyrimidines fused to 2H-chromen-2-oneand cyclohex-2-enone and pyrimidine fused to uracil via two component reaction of 4-amino-2H-chromen-2-one, 3-aminocyclohex-2-enone and6-aminouracilto 1-aryl-N,N'-bis(arylmethylene)methanediaminein the present of iodine as catalyst.Molecular iodine has received considerable attention in the last few years due to inexpensive, non-toxic, readily available and high tolerance to air for various organic transformations. In this reaction iodine has been used for activation of imine bond. The major benefits of the current study are high yields, short reaction times mild reaction conditions and available materials
Keywords:
Iodine ; Imines ; Pyrimidines ; Two Component Raction ; Uracil ; 2H-Chromen-2-One ; Cyclohex-2-Enone

No TOC