Loading...

Dynamic Simulation of HIV Infection and Its Control

Hajizadeh, Iman | 2013

708 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 44633 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Shahrokhi, Mohammad
  7. Abstract:
  8. This project presents appropriate strategies for HIV infection treatment. In order to close the presented strategy to real treatment regimen, appropriate parameters are selected for the HIV infection model, real outputs are considered for the system, and three widely used drugs (one PI: ritonavir (RDV), two RTIs: lamivudine (3TC) and zidovudine (ZDV)) are used to design a drug regimen. A Luenberger-like nonlinear observer (LNO) is also designed for estimation of unmeasurable states. In order to minimize the side effects of drug regimen, the concentration of ZDV is fixed at a minimum value at all time because this drug has a greater side effects than other drugs and the parameters of synthetic controllers are calculated based on maximization of an objective function to both reduce the side effects of another drugs and satisfy the control purposes. Also, a dynamic compensation scheme for input-constrained feedback linearizable nonlinear systems is applied to cope with the windup phenomenon. First a strategy is designed based on exact linearization control with considering the efficacy of the drugs be as inputs of the system. Then the overall stability of the closed-loop system in presence of input saturation is discussed. The previous strategy is far from reality because drug dosages are the real inputs of the system thus another strategy is designed based on impulsive linearizing control with considering the dosage of the drugs be as inputs of the system. The most important limitations in therapy design concern the uncertainty in the model parameters and the patient measurement periodicity. Understanding how the presented controller reacts to these limitations then becomes an important objective to be achieved through the work developed in this project
  9. Keywords:
  10. Nonlinear Observer ; HIV Infection ; Antiretroviral Drugs ; Exact Linearizing Controller ; Impulsive Linearizing Controller ; Input Saturation ; Leunberger-Like Observer

 Digital Object List

 Bookmark

No TOC