This project presents appropriate strategies for HIV infection treatment. In order to close the presented strategy to real treatment regimen, appropriate parameters are selected for the HIV infection model, real outputs are considered for the system, and three widely used drugs (one PI: ritonavir (RDV), two RTIs: lamivudine (3TC) and zidovudine (ZDV)) are used to design a drug regimen. A Luenberger-like nonlinear observer (LNO) is also designed for estimation of unmeasurable states. In order to minimize the side effects of drug regimen, the concentration of ZDV is fixed at a minimum value at all time because this drug has a greater side effects than other drugs and the parameters of...
This project presents appropriate strategies for HIV infection treatment. In order to close the presented strategy to real treatment regimen, appropriate parameters are selected for the HIV infection model, real outputs are considered for the system, and three widely used drugs (one PI: ritonavir (RDV), two RTIs: lamivudine (3TC) and zidovudine (ZDV)) are used to design a drug regimen. A Luenberger-like nonlinear observer (LNO) is also designed for estimation of unmeasurable states. In order to minimize the side effects of drug regimen, the concentration of ZDV is fixed at a minimum value at all time because this drug has a greater side effects than other drugs and the parameters of...