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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 45393 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Frounchi, Masoud
- Abstract:
- In this work, magnetite (Fe3O4) nanoparticles with an average siz21.9nm
modified by oleic acid were prepared by the coprecipitation method, which can linked well with organic molecules because of the presence of C-O-C on their surface. Then magnetic poly(lactic acid) (PLA)/ poly(ethylene glycol) (PEG) microspheres were prepared by the single emulsion solvent evaporation technology. The incorporation of magnetit nanoparticles and dox into the PLA matrix was confirmed by FTIR. XRD and VSM confirmed the existence of MNPs in the microspheres which maintained superparamagnetic behavior with a saturation magnetization of 50.69 emu/g.Electron microscopy SEM showed that the magnetic microspheres were spherical in shape with a smooth surface, and of a mean diameter is between 0.86-2 µm. A response surface methodology based on Central-Composite Design (BBD) was used to predict the maximum release behavior of doxorubicin. In optimum conditions (Fe3O4 concentration 16.71%w/w and PEG concentration 20% w/w), the minimum experimental release percentage was obtained 75.5% which was in good agreement with the predicted value by the CCD analysis (76.2%). The obtained results were in accordance with Korsmeyer model - Keywords:
- Polylactic Acid ; Doxorubicin ; Central Composite Design ; CONTROLLED RELEASE ; Magnetic Microsphere ; Krosmeyer Model
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