Coarse Grain Molecular Dynamics Simulation of Drug Carrier Translocation into Cell Membrane, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firoozabadi, Bahar (Supervisor)
Abstract
With the increasing development of the pharmaceutical industry and producing drugs with specific performance, its transfer into cells is also very important. Cell membranes are effectively impermeable to hydrophilic compounds unless the permeation is facilitated by dedicated transport systems. This means that many hydrophilic compounds, including many promising drug candidates, fail to reach their intracellular target because they cannot spontaneously cross lipid membranes. As a consequence, there is much interest in finding ways to facilitate the transport of molecules across cell membranes. Cell-penetrating peptides (CPPs) in particular have shown much promise as potential delivery agents...
Cataloging briefCoarse Grain Molecular Dynamics Simulation of Drug Carrier Translocation into Cell Membrane, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firoozabadi, Bahar (Supervisor)
Abstract
With the increasing development of the pharmaceutical industry and producing drugs with specific performance, its transfer into cells is also very important. Cell membranes are effectively impermeable to hydrophilic compounds unless the permeation is facilitated by dedicated transport systems. This means that many hydrophilic compounds, including many promising drug candidates, fail to reach their intracellular target because they cannot spontaneously cross lipid membranes. As a consequence, there is much interest in finding ways to facilitate the transport of molecules across cell membranes. Cell-penetrating peptides (CPPs) in particular have shown much promise as potential delivery agents...
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