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Preparation and biological evaluation of [67 Ga]-labeled-superparamagnetic iron oxide nanoparticles in normal rats

Jalilian, A. R ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1524/ract.2009.1566
  3. Abstract:
  4. Gallium-67 labeled superparamagnetic iron oxide nanoparticles were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles with narrow size distribution were synthesized by co-precipitation technique using ferric and ferrous salts at molar ratio Fe3+/Fe2+=2:1 followed by structure identification using XRD, thermo gravimetric analysis , differential scanning calorimetric , vibrating sample magnetometer, high-resolution scanning electron microscopy,transmission electron microscopy and fourier transform infrared absorption techniques. In order to trace superparamagnetic iron oxide nanoparticles bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67Ga with a high labeling efficiency (over 96%, determined by RTLC method) and they also showed an excellent stability at room temperature for at least 4 days. The biodistribution of the radiolabeled superparamagnetic iron oxide nanoparticles was checked in normal male rats up to 24 hours compared with the free Ga3+ cation biodistribution. The data strongly support the alteration of the tracer accumulation in reticuloendothelial system while the stability of the complex is highly retained. The result is promising for determining the position of the nanoparticles injected into a tissue when hyperthermia treatment/imaging is applied in biomedical fields
  5. Keywords:
  6. Gallium-67 ; Superparamagnetic iron oxide nanoparticles ; Radiolabeling ; Stability ; Biodistribution
  7. Source: Journal of Nuclear Science and Technology ; Volume 97, Issue 1 , September , 2009 , Pages 51–56
  8. URL: http://www.degruyter.com/view/j/ract.2009.97.issue-1/ract.2009.1566/ract.2009.1566.xml