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Stimulus Signal Improvement in Order to Alleviate the Symptoms of Parkinson's Disease in Rat

Gholipour, Saman | 2014

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46035 (05)
  4. University: Sharif University of Technology
  5. Department: Electrical Engineering
  6. Advisor(s): Vosughi Vahdat, Bijan
  7. Abstract:
  8. Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra. The cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related. Some of the symptoms are: shaking, rigidity, slowness of movement and difficulty with walking and gait. Modern treatments are effective at managing the early motor symptoms of the disease, mainly through the use of levodopa and dopamine agonists. As the disease progresses these drugs eventually become ineffective and produce a complication called dyskinesia, marked by involuntary writhing movements. Diet and some forms of rehabilitation have shown some effectiveness at alleviating symptoms. Surgery and deep brain stimulation have been used to reduce motor symptoms as a last resort in severe cases where drugs are ineffective. Mechanism of deep brain stimulation is not clear. But proper selection of target areas and accuracy is vital in success of deep brain stimulation. Studying mouse, we used ECoG signal for better observation of changes. In this process using 6-hydroxydopamine we first implemented Parkinson’s model in rat. Studying beta band energy of ECoG signal we reached the ideal options for the parameters of the stimulus signal
  9. Keywords:
  10. Parkinson Disease ; Deep Brain Stimulation (DBS) ; 6-Hydroxy Dopamine (6-OHDA) ; Rat ; Synchronous Stimulation and Recording

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