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Feasibility Study of Capillary Blood Viscosity Estimation using MRI

Rafiei, Alireza | 2015

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46826 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Samadfam, Mohammad; Ashoor, Mansoor
  7. Abstract:
  8. Magnetic resonance imaging is one of non-invasive methods to measure the hemodynamic and morphologic parameters of tissues, especially brain tissues. Hemodynamic parameters monitoring in brain tissue is of significant importance in many majors such as detection of tumor occurrence, brain abnormalities, and track of treatment procedures. Blood is a suspension, comprised of plasma, red blood cells, white blood cells, platelet, etc. Plasma is a Newtonian fluid which is composed of proteins and has a constant viscosity in body temperature. Rheological properties of blood are highly dependent on mechanical and rheological properties of its cells and this dependence is multiplied in narrow vessels and capillaries. Blood viscosity, is one of the hemodynamic parameters that depends on many factors, such as hematocrit ratio, shear rates, capillary wall structures and etc. The aim of this project, is to study the feasibility of estimation of blood viscosity with use of nuclear magnetic resonance. In order to do this, with design of multiple capillary structures, dependence of transverse relaxation rate changes and hemodynamic parameters were calculated and analyzed for each designed structural model. Furthermore, flow rates, hematocrit ratio and blood apparent viscosity were calculated segment by segment for all structural models. These calculations showed that with increase in bifurcation angles, the flow resistance for model will increase. With analyzing the results obtained in two set of calculations, it was shown that there is a linear relation between transverse relaxation rate changes and blood apparent viscosity for each model
  9. Keywords:
  10. Capillary Network ; Magnetic Resonance Imagin (MRI) ; Diffusion ; Perfusion ; Blood Apparent Viscosity

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