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Solvent-free synthesis of 3-benzylpyrano[3,2-c]pyran/chromene-2,5-diones via tandem reaction of 4-hydroxy-6-methyl-pyran-2-one and 4-hydroxycoumarin with Baylis-Hillman adduct acetates

Matloubi Moghaddam, F ; Sharif University of Technology

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  1. Type of Document: Article
  2. Abstract:
  3. 4-hydroxycoumarin 2a and 4-hydroxy-6-methyl-pyran-2-one 2b were applied in a one-pot reaction with Baylis-Hillman adduct acetates 1 to form novel 3-benzylpyrano [3, 2-c] pyran-2, 5-diones 3 in high yields (70-85%). The synthesized framework is available in many biologically active moieties. The reaction was carried out under different conditions to achieve optimum conditions. The results indicated that Et3N, as a base under solvent-free conditions, was optimum. The reaction procedure and purification method are mild and straightforward
  4. Keywords:
  5. 4-hydroxycoumarin ; Annulated 2-pyrone ; Engineering ; Natural sciences ; Baylis-Hilman adduct acetate ; Optimum conditions ; Purification method ; Solvent free conditions ; Solvent free synthesis ; Acetate ; Coagulation ; Ketone ; Optimization ; Purification ; Solvent
  6. Source: Scientia Iranica ; Vol. 21, issue. 3 , 2014 , p. 735-741 ; 1026-3098 ; 2345-3605
  7. URL: http://www.scientiairanica.com/en/ManuscriptDetail?mid=392