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Simultaneous Spectrophotometric Determination of Lisinopril and Arginine Based on Charge-Transfer Complex Formation with 1,2-Naphthoquinone-4-Sulfonate and Colorimetric Determination of Chromium (III) Ion by Aggregation of Silver Nanoparticle Capped with Gallic Acid

Harif Bilondi, Marzieh | 2015

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 47158 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Hormozi Nezhad, Mohammad Reza
  7. Abstract:
  8. Multivariate calibration methods are used for simultaneous determination of two or more different species in the mixture of species. If the responses of species are similar, multivariate calibration has the ability of modeling the relation between responses and species concentration, too. Artificial neural networks, using as more applicable methods of nonlinear multivariate calibrations, when the relation is nonlinear, In the first part, lisinopril and arginine are simultaneously determined by artificial neural network. Separate calibration curves are obtained for lisinopril and arginine. Then spectra of reaction product of 38 different mixtures of two species with 1,2-naphthoquinone-4-sulfonate were recorded and the data matrix is given as input to the artificial neural network. For reducing of data size and increasing of the speed of the network, principal component analysis was applied to the data matrix, before the artificial neural network. Linear ranges of lisinopril and arginine individually were 10.0-260.0 and 10.0-300.0 µM, respectively. Linear range of 10.0-120.0 µM for simultaneous determination was selected. Silver nanoparticles have attracted a lot of attention between colorimetric sensors, because this plasmonic nanoparticle have intense and sharp peak in the visible region, and also changes color of them due to the accumulation. In the second part, a simple, fast and an efficient method for synthesis of silver nanoparticle at alkaline media by gallic acid as reducer and stabilier was introduced. Chromium (III) ion induces aggregation of silver nanoparticles and changing the color of solution, through complexation with gallic acid on nanoparticles surface. By this method, linear range and detection limit of chromium (III) ion was 3.5-17.5 µM and 2.0 µM, respectively
  9. Keywords:
  10. Artificial Neural Network ; Colorimetric ; Silver Nanoparticles ; Aggregation Method ; Simultaneous Determination ; Lisinopril ; Chromium (III)Ion ; 1,2-Nephtoquinone-4-Sufonate

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