Loading...

Mathematical Modeling of Diabetic Nephropathy

Tavakolian, Mandana | 2015

710 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 47285 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abd Khodaei, Mohammad Jafar; Bozorgmehri, Ramin
  7. Abstract:
  8. Diabetes has become the most prevalent disease all among the world. One of the complications of this disease is diabetic nephropathy. Diabetic nephropathy occurs when the kidney cells encounter high glucose concentration for long periods. Kidney cells use glucose as their energy supply. However, the excess glucose in the diabetics triggers specific gene pathways, gradually leading to diabetic nephropathy. As a result, proteins’ levels and the activity of transcription factors change during the disease progression. Diabetic nephropathy is characterized by excessive deposition of the proteins comprising the extracellular matrix in the mesangium, basement membrane of the glomerulus, and in the renal tubulointerstitium. In this project, we first identified the most important proteins that affect the former process. These proteins are highly interconnected, and altogether form the main gene pathway for this disease. Based on the causal relations (activation and repression), a rate equation can be written or each protein. The fuzzy signed directed graph method was used to calculate the rate constants. The end-of-chain proteins in the gene pathway were considered as an index of diabetic nephropathy progression. Using the available experimental data, the implemented fuzzy system was designed in way to capture the effects of the following input parameters: blood glucose level, age, sex, body mass index, smoking habits, blood pressure, and angiotensin convertor enzyme inhibitor uptake. Consequently, the proposed model is capable of estimating the temporal progression of diabetic nephropathy in a patient, given the former input parameters
  9. Keywords:
  10. Proteins ; Mathematical Modeling ; Directed Graph ; Fuzzy Logic ; Diabetical Nephropathy

 Digital Object List

 Bookmark

No TOC