Evaluation of Base Calling Methods in Next Generation Sequencing, M.Sc. Thesis Sharif University of Technology ; Hossein Khalaj, Babak (Supervisor) ; Motahhari, Abolfazl (Supervisor)
Abstract
In the mid twentieth century by discovering the existence of genetic strands and understanding their role in diseases and phenotypes of species, research initiated to decipher their content. Sequencing of the first human genome at early twenty-first century paved the way to study and even cure complex human deseases having genetic origin. Next Generation Sequencing (NGS) Technologies have significantly reduced the expenses and the timing complexity of DNA Sequencing and this has an improving trend. In this thesis, we evaluate Base Calling methods, a critical step in analyzing next generation sequencing information and deals with massive sequencing data. Base Calling tries to optimally detect...
Cataloging briefEvaluation of Base Calling Methods in Next Generation Sequencing, M.Sc. Thesis Sharif University of Technology ; Hossein Khalaj, Babak (Supervisor) ; Motahhari, Abolfazl (Supervisor)
Abstract
In the mid twentieth century by discovering the existence of genetic strands and understanding their role in diseases and phenotypes of species, research initiated to decipher their content. Sequencing of the first human genome at early twenty-first century paved the way to study and even cure complex human deseases having genetic origin. Next Generation Sequencing (NGS) Technologies have significantly reduced the expenses and the timing complexity of DNA Sequencing and this has an improving trend. In this thesis, we evaluate Base Calling methods, a critical step in analyzing next generation sequencing information and deals with massive sequencing data. Base Calling tries to optimally detect...
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