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Sensitive electrochemical sensor for determination of methyldopa based on polypyrrole/carbon nanoparticle composite thin film made by in situ electropolymerization

Shahrokhian, S ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1002/elan.201100169
  3. Publisher: 2011
  4. Abstract:
  5. A composite surface coating is prepared by electropolymerization of a mixture of pyrrole and carbon nanoparticles onto a glassy carbon electrode (GCE). The microscopic structure and morphology of the composite film is characterized by scanning electron microscopy. The modified electrode offers a considerable improvement in voltammetric sensitivity toward methyldopa (m-dopa), compared to the bare and polypyrrole-coated GCEs. A significantly enhanced anodic peak current together with a remarkable increase in sharpness of the cyclic voltammetric (CV) signals are observed for the detection of m-dopa. The effect of experimental parameters, such as scan rate and pH, are investigated by monitoring CV responses toward m-dopa. It is found that a maximum current response can be obtained at pH3.0 under a diffusion controlled process. A wide linear dynamic range (0.2-50μM) with a detection limit of 60nM is achieved for m-dopa. The excellent response characteristics, e.g., high sensitivity, very good repeatability and reproducibility, and low detection limit, have made the prepared sensor suitable for the analysis of m-dopa in pharmaceutical and clinical preparations
  6. Keywords:
  7. Carbon nanoparticles ; Composite electrodes ; Methyldopa ; Modified electrodes ; Polypyrrole
  8. Source: Electroanalysis ; Volume 23, Issue 9 , 2011 , Pages 2248-2254 ; 10400397 (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/elan.201100169/abstract;jsessionid=C368AF66FD97BC70FB6F819415A61756.f02t03?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+14th+May+11%3A00-14%3A00+BST+%2F+06%3A00-09%3A00+EDT+%2F+18%3A00-21%3A00+SGT+for+essential+maintenance.Apologies+for+the+inconvenience