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Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

Mahmoudi, M ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1016/j.addr.2010.05.006
  3. Publisher: 2011
  4. Abstract:
  5. At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together with their possibilities and limitations from fabrication to application in drug delivery. In addition, the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes are described
  6. Keywords:
  7. Coatings ; Drug delivery ; SPIONs ; Surfaces ; Biomedical applications ; Cancer therapy ; Drug delivery applications ; Side effect ; Surface architectures ; Surface modification ; Synthetic routes ; Nanoparticles ; Superparamagnetism ; Toxicity ; Iron oxides ; Acetylsalicylic acid ; Alpha2b interferon ; Camptothecin ; Carubicin ; Cisplatin ; Dexamethasone acetate ; Doxorubicin ; Epirubicin ; Ferric oxide ; Ibuprofen ; Magnetite ; Mitoxantrone ; Paclitaxel ; Rubomycin ; Superparamagnetic iron oxide nanoparticle ; Tamoxifen ; Antiinflammatory activity ; Blood brain barrier ; Chemical composition ; Chemical modification ; Chemical structure ; Chemotherapy ; Chill ; Colloid ; Crystallization ; Cytotoxicity ; Drug bioavailability ; Drug coating ; Drug delivery system ; Drug distribution ; Drug efficacy ; Drug release ; Drug research ; Drug targeting ; Drug tolerability ; Glioma ; Isotope labeling ; Magnetic field ; Molecular imaging ; Molecular stability ; Nanoencapsulation ; Nonhuman ; Osteosarcoma ; Particle size ; Priority journal ; Protein interaction ; Review ; Solid tumor ; Squamous cell carcinoma ; Surface charge ; Surface property ; Synthesis ; Toxicity testing ; Transmission electron microscopy ; Animals ; Antineoplastic Agents ; Drug Delivery Systems ; Humans ; Magnetite Nanoparticles
  8. Source: Advanced Drug Delivery Reviews ; Volume 63, Issue 1-2 , January–February , 2011 , Pages 24-46 ; 0169409X (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0169409X1000133X