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Functional Mapping of Regions Involved In Addiction Using Magnetic Resonance Imaging and Proposing a New Measure for Multivariate Methods
Faghiri, Ashkan | 2016
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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 48287 (05)
- University: Sharif University of Technology
- Department: Electrical Engineering
- Advisor(s): Vosughi Vahdat, Bijan; Ekhtiari, Hamed
- Abstract:
- Methamphetamine (meth) abuse and addiction (MA), with its serious medical, psychiatric and social complications, is a growing national disaster in Iran. Response control deficit during exposure to drug related cues is one of the main neurocognitive cores in MA and results in continued drug use and treatment failure. There have been many studies focused on cue exposure, but most of their paradigms required subjects to passively view the cues; this aspect of these paradigms cause a wide gap between reality and experimental studies. Developing a functional and structural neuroimaging protocol to map realistic brain circuits that are involved in craving among meth users is of importance. Providing etiologic neural evidences will enable us to develop and monitor effective therapeutic interventions and long term neurorehabilitations to be added to the current addiction treatment services to enhance treatment outcomes. In this project, a new paradigm is designed which has simultaneous craving and executive processes. In addition negative cues are also included to enable us compare these to craving cues. The designed task will have a mixed design which is a great advantage as it will let us analysis the results with different methods. 60 Methamphetamine addicts (age 20-40, man, right-handed, in treatment) will undergo scanning while doing the said paradigms. As Multivariate methods have more sensitivity than univariate ones, the main analysis done on the data will be multivariate classification analysis. In this analysis we will be using searchlight methods to explore the regions of the brain which have information that can help distinguish between craving and neutral stimuli. At last a new measure will be proposed which can be interpret more easily
- Keywords:
- Addiction ; Methamphtamine ; Functional Magnetic Resonance Imaging (FMRI) ; Multivariate Methods ; Uinivariate Methods
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