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Voltammetric behavior and determination of trace amounts of omeprazole using an edge-plane pyrolytic graphite electrode

Shahrokhian, S ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. Publisher: Iranian Journal of Pharmaceutical Research , 2015
  3. Abstract:
  4. The voltammetric performance of edge-plane pyrolytic graphite (EPG) electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole (OMZ) in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism. The determination conditions, such as the pH values of the supporting electrolyte, accumulation time and scan rate were optimized. Simplicity, high reproducibility and low detection limit (3 nM) of the electrode response as well as wide linear range (0.01 to 4.0 µM) can be stated as significant features of this electrode. The EPG electrode was successfully applied for the determination of OMZ in pharmaceutical formulations and satisfactory results were obtained
  5. Keywords:
  6. Omeprazole ; Pharmaceutical analysis ; Pyrolytic graphite electrode ; Voltammetry ; Accumulation time ; edge plane pyrolyti ghraphite electrode ; Electric conductivity ; Electric potential ; Electrochemical analysis ; Electrochemistry ; Electrode ; Electrode response ; Oxidation ; PH ; Potentiometry
  7. Source: Iranian Journal of Pharmaceutical Research ; Volume 14, Issue 2 , Spring , 2015 , Pages 465-471 ; 17350328 (ISSN)
  8. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403062