Hydrodynamic Simulation of Vascular Scaffolds, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Mashayekhan, Shohreh (Supervisor)
Abstract
This research studies a 3D channeled myocardium scaffold with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of oxygen carriers and scaffold geometry on cell growth in a 3D cardiac construct. The modeling results show that using 5.4% perfluorocarbon oxygen carrier (PFC) has increased cardiac cells density 15% of the initial seeded cells comparing to pure culture medium without PFC supplementation. Effects of the scaffold geometry on cell density in the construct were examined by increasing channel numbers and changing the construct length. The results show that increasing channel numbers (by 50% decreasing channels diameter and wall to wall spacing) the...
Cataloging briefHydrodynamic Simulation of Vascular Scaffolds, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Mashayekhan, Shohreh (Supervisor)
Abstract
This research studies a 3D channeled myocardium scaffold with computational fluid dynamics. It proposes a mathematical model to evaluate the impact of oxygen carriers and scaffold geometry on cell growth in a 3D cardiac construct. The modeling results show that using 5.4% perfluorocarbon oxygen carrier (PFC) has increased cardiac cells density 15% of the initial seeded cells comparing to pure culture medium without PFC supplementation. Effects of the scaffold geometry on cell density in the construct were examined by increasing channel numbers and changing the construct length. The results show that increasing channel numbers (by 50% decreasing channels diameter and wall to wall spacing) the...
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