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Electrochemical determination of naltrexone on the surface of glassy carbon electrode modified with Nafion-doped carbon nanoparticles: Application to determinations in pharmaceutical and clinical preparations

Ghorbani Bidkorbeh, F ; Sharif University of Technology

2008 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.jelechem.2009.11.012
  3. Abstract:
  4. A new sensitive and selective electrochemical sensor was developed for determination of naltrexone (NAL) in pharmaceutical dosage form and human plasma. Naltrexone is an opioid antagonist which is commonly used for the treatment of narcotic addiction and alcohol dependence. A voltammetric study of naltrexone has been carried out at the surface of glassy carbon electrode (GCE) modified with Nafion-doped carbon nanoparticles (CNPs). The electrochemical oxidation of naltrexone was investigated by cyclic and differential pulse voltammetric techniques. The dependence of peak currents and potentials on pH, concentration and the potential scan rate was investigated. The electrode characterization by electrochemical methods and atomic force microscopy (AFM) showed that CNPs enhanced the electroactive surface area and accelerated the rate of electron transfer. Application of the modified electrode resulted in a sensitivity enhancement of more than 20 times, relative to the bare GCE, in detection of NAL and a considerable negative shift in peak potential was achieved. Two linear dynamic ranges of 1-10 μM and 10-100 μM with a detection limit of 0.1 μM was obtained in phosphate buffer of pH = 3. Differential pulse voltammetry as a simple, rapid, sensitive and selective method was developed for the determination of NAL in dosage form and human plasma without any treatments. No electroactive interferences were found in biological fluids from the endogenous substances and additives present in capsules
  5. Keywords:
  6. Modified electrode ; Biological fluids ; Carbon nano particles ; Detection limits ; Differential pulse ; Differential pulse voltammetry ; Doped carbons ; Dosage forms ; Electroactive interference ; Electroactive surface areas ; Electrochemical determination ; ELectrochemical methods ; Electrode characterization ; Electron transfer ; Endogenous substances ; Glassy carbon electrodes ; Human plasmas ; Linear dynamic ranges ; Modified electrodes ; Nafion ; Naltrexone ; Narcotic addiction ; Negative shift ; Peak currents ; Peak potentials ; Pharmaceutical dosage forms ; Phosphate buffers ; Scan rates ; Sensitivity enhancements ; Voltammetric studies ; Voltammetric techniques ; Atomic force microscopy ; Chemical detection ; Drug products ; Electrochemical oxidation ; Electrochemical sensors ; Electrodes ; Glass membrane electrodes ; Glassy carbon ; Nanoparticles ; Plasma (human) ; Voltammetry
  7. Source: Journal of Electroanalytical Chemistry ; Volume 638, Issue 2 , 2010 , Pages 212-217 ; 15726657 (ISSN)
  8. URL: http://www.sciencedirect.com/science/article/pii/S002207280900429X